Clinicopathological Evaluation of Pigmented Skin Lesions: A Retrospective – Analytical Study

Clinicopathological Evaluation of Pigmented Skin Lesions: A Retrospective – Analytical Study

Author(s): Shokouh Taghipour Zahir
Citation: M Akhavan, S T Zahir, P Kamal. (2024). Clinicopathological Evaluation of Pigmented Skin Lesions: A Retrospective –Analytical Study. Journal of Dermatological Research and Plastic Surgery, The Geek Chronicles. 1(1):1-9
Address / Description:

1 Assistant Professor of clinical and surgical pathology, Shahid Sadoughi University of Medical Sciences, Yazd,Iran.

2* Full Professor of clinical and surgical pathology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

3 General pathologist, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Copyright: © 2024 S T Zahir, this is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Received On: June 14, 2024
Accepted On: June 28, 2024
Published On: July 4, 2024
Abstract:

Background and Objective: We aimed to study various pigmented skin lesions (benign and malignant) and their clinicopathological characteristics to prevent malignant lesions progression and early detection of them from benign ones.

Methods: This descriptive cross-sectional retrospective study was done by census sampling method on all patients referred to the Department of Dermatology with pigmented skin lesions who underwent biopsy between 2010-2020. Patients’ data were extracted from the pathology ward by pre- prepared checklist that included age, sex, pathology report, margins status, and anatomical location. Data were entered into SPSS22 software, and analyzed by Chi-square and ANOVA tests.  A P-value less than 0.05 was considered statistically significant.

Result: Totally 1127 patients with a mean age of 46.55 +_ 21.03 were studied. Of these, 46% were male and 54% were female. Benign lesions were 66.7% and malignant lesions were 33.3%. The most common malignant lesions were epithelial tumors (85.6%) and malignant melanoma respectively. The correlation between malignant lesions and Patients’ age was statistically significant (p-value=0.025). Benign lesions were most common in patients between 19 to 39 years old. Head and neck were the most common sites for both malignant and benign pigmented skin lesions. The overall frequency of lesion size was between 0.5 – 0.74 cm. In 84.3% of the lesions, the margins were free from the tumors.

Conclusion: All pigmented skin lesions in elderly persons require investigation to exclude malignancy, especially malignant melanoma.

Keywords: pigmented skin lesions, melanoma, melanocytic nevus, non- melanocytic pigmented lesions

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